Randy Weiner, DMD, continues his 4-part series on the types of liners, bases, and cements and their clinical applications. This article will discuss 2 other materials than can be used as a liner, base, and/or cement: the glass ionomer-based and resin-based materials. After reading this article, the individual will have a better understanding of glass ionomers and resins and how they work along with a better understanding of how to appropriately use glass ionomers and resin in clinical practice.