In this peer-reviewed article, Anshul Mehra, BDS, DDS, and Suneet Kumar, MBBS, MD, review the clinical features, treatment, and prognosis of systemic sclerosis, including periodontal manifestations. After reading this article, the individual will learn the etiology, pathogenesis, clinical features, oral manifestations, and treatment of scleroderma, and the periodontal manifestations seen in patients with systemic sclerosis.